Therapeutic area: thrombophilia

Factor II (Prothrombin 20210 G>A)

General Use: 

The Factor II (prothrombin) polymorphism raises the risk of thrombosis significantly for both males and females in all age groups. People with this polymorphism are at 2- to 3-fold increased risk of deep venous thrombosis (DVT), without other confounding non-genetic factors such as smoking, hormone therapy, and immobility.

Limitations: 

Other genetic variants of the Factor II gene that are not detected in the assay may influence Factor II enzymatic activity. Other genetic and non-genetic factors may also influence the balance of proper coagulation.

Methodology: 

Real-time polymerase chain reaction with fluorescence detection.

Analytes Detected: 

20210 G>A