Therapeutic area: thrombophilia

Factor II (Prothrombin 20210 G>A)

General Use: 

The Factor II (prothrombin) polymorphism raises the risk of thrombosis significantly for both males and females in all age groups. People with this polymorphism are at 2- to 3-fold increased risk of deep venous thrombosis (DVT), without other confounding non-genetic factors such as smoking, hormone therapy, and immobility.


Other genetic variants of the Factor II gene that are not detected in the assay may influence Factor II enzymatic activity. Other genetic and non-genetic factors may also influence the balance of proper coagulation.


Real-time polymerase chain reaction with fluorescence detection.

Analytes Detected: 

20210 G>A